Pantothenic acid, commonly known as vitamin B5 and when bound to calcium as D-Calcium Pantothenate, serves as a pivotal component in the biosynthesis of coenzyme A (CoA) — a coenzyme involved in the synthesis and oxidation of fatty acids, as well as in the Krebs cycle. This vitamin is instrumental in various metabolic pathways, including those that generate energy from carbohydrates, proteins, and fats. Beyond its metabolic roles, emerging research points to its potential in addressing neurodegenerative diseases and promoting neurological health.
A recent study highlighted the role of pantothenic acid in the brain's energy metabolism and proposed its deficiency as a potentially reversible cause of neurodegeneration and dementia, including in conditions such as sporadic Alzheimer's disease (Xu et al., 2020). This groundbreaking insight opens new avenues for therapeutic strategies aimed at replenishing pantothenic acid levels in the brain to combat or slow the progression of neurodegenerative diseases.
In addition to neurological benefits, pantothenic acid has been shown to play a role in enhancing immune function, wound healing, and reducing oxidative stress. Its role in fatty acid synthesis is particularly notable, as it supports the structural and functional integrity of cellular membranes and the production of various signaling molecules.
Despite its widespread availability in various foods, deficiencies can occur and supplementation may be beneficial in certain conditions. The pharmacokinetics of orally administered calcium pantothenate have been studied in healthy adults, showcasing its safety profile and laying the groundwork for further clinical investigations into its therapeutic potential (Rao et al., 2021).
In summary, pantothenic acid stands as a critical nutrient in human health, particularly for its contributions to metabolic processes, energy production, and neurological health. Continued research and clinical trials will further elucidate its full therapeutic potential and application in disease prevention and management.
References
- Xu, J., Patassini, S., Begley, P., Church, S. J., Waldvogel, H., Faull, R., Unwin, R., & Cooper, G. (2020). Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease. Biochemical and Biophysical Research Communications. Cerebral deficiency of vitamin B5
- Rao, S., Wade, A., Sinha, U., Shaywitz, A., Virani, S. N., Gretler, D., Reilly, T., Morimoto, B. H., & Escandon, R. (2021). The Pharmacokinetics of Orally Administered Calcium Pantothenate in Healthy Adults. Journal of Vitamins and Minerals. The Pharmacokinetics of Orally Administered Calcium Pantothenate in Healthy Adults
